Type 1 Diabetes Mellitus (T1DM) is a chronic, progressive and severe Illness characterized by a destruction or failure of insulin-secreting pancreatic beta cells, usually as a result of an autoimmune response. The resulting insulin deficiency prevents insulin-sensitive cells from executing vital glucose metabolism and leads to hyperglycemia (higher blood glucose levels). As a result, immediate and lifelong treatment along with exogenous insulin therapy is initiated upon diagnosis of T1DM. Exogenous insulin has actually remained the mainstay of T1DM therapy because it was used to handle the very first human patient in 1922.
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Consequently, insulin products make up the vast majority of the T1DM market, which is largely monopolized by 3 big pharma players: Eli Lilly, Novo Nordisk and Sanofi. However, insulin treatment programs are regularly inconvenient and are associated along with unhealthy adverse effects such as hypoglycemia (reasonable blood glucose levels) and weight gain. In addition, there is a substantial unmet requirement for much more diversified treatment selections including therapies capable of altering the clinical road of the pathological beta cell destruction and adjuvant therapies capable of boosting glycemic manage and cutting down insulin requirements.
Licensing and co-improvement deals between significant pharmaceutical companies adore ViaCyte, Janssen Research & Development, Eli Lilly, MacroGenics, Bayhill Therapeutics, Genentech, Nuvilex, Sanofi, MannKind, GlaxoSmithKline, Tolerx, Osiris Therapeutics, JHL Biotech and others is included in the report.
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Scope of the report:
The report assesses the latest T1DM market and forecasts market trends to 2021. Locations covered contain –
– An introduction to T1DM, which entails classification, symptoms, etiology, pathophysiology, co-morbidities and complications, diagnosis and treatment.
– An analysis of the leading insulin therapies in the latest T1DM marketed products landscape.
– An analysis of the pipeline for T1DM. This entails a breakdown of pipeline molecules by phase of development, molecule type, route of administration, molecular target and novelty. Trends in T1DM clinical trial size, duration and failure rates, by molecule type and molecular target are discussed. A comparative analysis of the many promising pipeline molecules is additionally provided.
– Forecast projections for the T1DM market to 2021. An analysis is given for the global market and each of the eight significant markets. The forecast incorporates projected, reasonable and higher variance scenarios based on treatment usage patterns and annual therapy costs in each of the significant markets.
– An analysis of strategic consolidations, including co-improvement and licensing deals, within the T1DM indication.
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How beneficial is the report?
The report will certainly give clients along with a solid discovering of the T1DM indication and an appreciation of the evolving landscape of the T1DM therapeutics market. The report will certainly allow clients to –
– Appreciate the latest T1DM marketed products landscape, including the dominant therapeutic strategies, products, and companies, and realize gaps within the market and Locations of unmet need.
– Identify trends and developments within the T1DM pipeline and think about Exactly how the future competitive environment will certainly be impacted.
– think about market chances and potential risks by examining trends in T1DM clinical trial duration and size, also as clinical trial failure rates, amongst clinical phases and molecule types.
– Assess the potential clinical and commercial impact of current late-phase pipeline molecules on the T1DM therapeutics market.
– know Exactly how strategic consolidations have actually shaped the latest T1DM pipeline and marketed products landscapes.
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