Impact of diabetes mellitus on the survival of pancreatic cancer: a meta-analysis – Dove Medical Press

Authors Shen H, Zhan M, Wang W, Yang D, Wang J

Received 4 September 2015

Accepted for publication 11 December 2015

Published 22 March 2016 Volume 2016:9 Pages 1679—1688

DOI http://ift.tt/1Pq68aM

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ram Prasad

Peer reviewer comments 3

Editor that approved publication: Professor Barbara Burtness

Hui Shen, Ming Zhan, Wei Wang, Dong Yang, Jian Wang

Department of Biliary-Pancreatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China

Background: Diabetes mellitus (DM) is a danger explanation for pancreatic cancer (PC), however its prognostic value in PC is still unclear. To elucidate this issue, we systematically reviewed the proof regarding the association in between diabetes status and PC.
Methods: Medline and EMBASE databases were searched to recognize the eligible studies. General and subgroup analyses were executed to detect the inequality of prognosis according to diabetes status. Hazard ratios (HRs) along with 95% CI were utilized to estimate the effect size.
Results: Eighteen studies consisting of 16,181 patients along with sample dimension ranging from 11three to 4,65eight were pooled in this meta-analysis. Outcomes showed that patients along with DM possessed even worse survival (HR 1.19, 95% CI: 1.07–1.32). In see of the affect of diabetes duration and tumor phase about the outcomes, we classified the studies in to various groups. The Outcomes suggested that DM was associated along with survival in the 2 long-status diabetes (HR 1.26, 95% CI: 1.14–1.40) and recent-onset diabetes (HR 1.29, 95% CI: 1.09–1.51). Data about localized illness (HR 1.57, 95% CI: 1.00–2.46) and nonlocalized (locally advanced and metastatic) illness (HR 1.42, 95% CI: 1.16–1.73) verified that the prognostic value was independent of tumor stage.
Conclusion: Our Outcomes advised that patients along with DM were associated along with even worse survival compared to those devoid of DM. Diabetes could be a predictive explanation of survival in patients along with PC. Surveillance of diabetes status and antidiabetes medication administration after the diagnosis of PC is of medical importance.

Keywords: diabetes mellitus, pancreatic cancer, survival, meta-analysis

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